A molecular staging model for accurately dating the endometrial biopsy.

ABSTRACT: Natural variability in menstrual cycle length, coupled with rapid changes in endometrial gene expression, makes it difficult to accurately define and compare different stages of the endometrial cycle. Here we develop and validate a method for precisely determining endometrial cycle stage based on global gene expression. Our 'molecular staging model' reveals significant and remarkably synchronised daily changes in expression for over 3400 endometrial genes throughout the cycle, with the most dramatic changes occurring during the secretory phase. Our study significantly extends existing data on the endometrial transcriptome, and for the first time enables identification of differentially expressed endometrial genes with increasing age and different ethnicities. It also allows reinterpretatio

SUBMITTER: Teh WT 

PROVIDER: S-EPMC10556104 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature