Cellular Therapy in NSCLC: Between Myth and Reality.

ABSTRACT:

Purpose of review

In this paper, we review the current state and modalities of adoptive cell therapies (ACT) in non-small cell lung carcinoma (NSCLC). We also discuss the challenges hampering the use of ACT and the approaches to overcome these barriers.

Recent findings

Several trials are ongoing investigating the three main modalities of T cell-based ACT: tumor-infiltrating lymphocytes (TILs), genetically engineered T-cell receptors (TCRs), and chimeric antigen receptor (CAR) T cells. The latter, in particular, has revolutionized the treatment of hematologic malignancies. However, the efficacy against solid tumor is still sparse. Major limitations include the following: severe toxicities, restricted infiltration and activation within the tumors, antigen escape and heterogene

SUBMITTER: Imbimbo M 

PROVIDER: S-EPMC10556121 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature