History of traumatic brain injury does not alter course of neurocognitive decline in older adults with and without cognitive impairment.

ABSTRACT:

Objective

Traumatic brain injury (TBI) history is associated with dementia risk, but it is unclear whether TBI history significantly hastens neurocognitive decline in older adults.

Method

Data were derived from the National Alzheimer's Coordinating Center (NACC) data set. Participants with a history of TBI (TBI +; n = 1,467) were matched to individuals without a history of TBI (TBI-; n = 1,467) based on age (50-97, M = 71.61, SD = 8.40), sex, education, race, ethnicity, cognitive diagnosis, functional decline, number of Apolipoprotein ε4 (APOE ε4) alleles, and number of annual visits (3-6). Mixed linear models were used to assess longitudinal neuropsychological test composite scores of executive functioning/attention/speed, language, and memory in

SUBMITTER: Schaffert J 

PROVIDER: S-EPMC10556197 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature