Digital image analysis allows objective stratification of patients with silent PIT1-lineage pituitary neuroendocrine tumors.

ABSTRACT: Studies describing the clinical presentation and prognosis of patients with silent PIT1 (pituitary specific transcription factor)-lineage pituitary neuroendocrine tumors (PitNETs) are rare. We identified patients with positive PIT1 tumor staining but without evidence of hormone hypersecretion at a tertiary center. Clusters were obtained according to cell morphology and immunostaining from each patient's digitally segmented whole slide image. We compared the clinical presentations, radiological features, and prognoses of the different clusters. We identified 146 patients (68 male, 42.9 ± 14.1 years old) with silent PIT1-lineage PitNETs. Morphology clustering suggested that tumors with large nuclei and apparent eccentricity were associated with a higher proportion of aggressiveness and a hig

SUBMITTER: Zhao J 

PROVIDER: S-EPMC10556262 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature