Modest Effects of Osteoclast-Specific ERα Deletion after Skeletal Maturity.

ABSTRACT: Estrogen regulates bone mass in women and men, but the underlying cellular mechanisms of estrogen action on bone remain unclear. Although both estrogen receptor (ER)α and ERβ are expressed in bone cells, ERα is the dominant receptor for skeletal estrogen action. Previous studies using either global or cell-specific ERα deletion provided important insights, but each of these approaches had limitations. Specifically, either high circulating sex steroid levels in global ERα knockout mice or the effects of deletion of ERα during growth and development in constitutive cell-specific knockout mice have made it difficult to clearly define the role of ERα in specific cell types in the adult skeleton. We recently generated and characterized mice with tamoxifen-inducible ERα deletion in osteocytes dr

SUBMITTER: Doolittle ML 

PROVIDER: S-EPMC10556268 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature