Update on Cannabidiol Clinical Toxicity and Adverse Effects: A Systematic Review.

ABSTRACT:

Background

Compelling evidence from preclinical and clinical studies supports the therapeutic role of cannabidiol (CBD) in several medical disorders. We reviewed the scientific evidence on CBD-related toxicity and adverse events (AEs) in 2019, at the beginning of the spike in clinical studies involving CBD. However, CBD safety remained uncertain.

Objective

With the benefit of hindsight, we aimed to provide an update on CBD-related toxicity and AEs in humans.

Methods

A systematic literature search was conducted following PRISMA guidelines. PubMed, Cochrane, and Embase were accessed in October 2022 to identify clinical studies mentioning CBDrelated toxicity/AEs from February 2019 to September 2022. Study design, population characteristics, CBD doses, treatment duration,

SUBMITTER: Madeo G 

PROVIDER: S-EPMC10556379 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature