Identifying prodromal symptoms at high specificity for Parkinson's disease.

ABSTRACT:

Introduction

To test drugs with the potential to prevent the onset of Parkinson's disease (PD), it is key to identify individuals in the general population at high risk of developing PD. This is often difficult because most of the clinical markers are non-specific, common in PD but also common in older adults (e.g., sleep problems).

Objective

We aimed to identify the clinical markers at high specificity for developing PD by comparing individuals with PD or prodromal PD to healthy controls.

Methods

We investigated motor and non-motor symptoms (Movement Disorder Society Unified Parkinson's Disease Rating Scale Part 1 and 2 items) in 64 prodromal PD and 422 PD individuals calculating the odds ratios, adjusting for age and gender, for PD and prodromal PD versus 195 health

SUBMITTER: Jackson H 

PROVIDER: S-EPMC10556459 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature