A novel oncolytic virus-based biomarker participates in prognosis and tumor immune infiltration of glioma.

ABSTRACT:

Background

Glioma is the most common central nervous malignancy. Due to its poor survival outcomes, it is essential to identify novel individualized therapy. Oncolytic virus (OV) treatment is a key therapy regulating tumor microenvironment in malignant glioma. Herein, we aim to identify the key genes after OV infection and its role in glioma.

Methods

Performing an RNA-seq analysis, the differentially expressed genes (DEGs) between EV-A71-infection and mock group were screened with GFold values. DAVID online analysis was performed to identify the functional classification. Overall survival (OS) or disease-free survival (DFS) was evaluated to analyze the relation between PTBP1 expression levels and prognosis of glioma patients. Additionally, the ssGSEA and TIMER algorithms wer

SUBMITTER: Hao Z 

PROVIDER: S-EPMC10556503 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature