Structure of the bc₁-cbb₃ respiratory supercomplex from Pseudomonas aeruginosa.

ABSTRACT: Energy conversion by electron transport chains occurs through the sequential transfer of electrons between protein complexes and intermediate electron carriers, creating the proton motive force that enables ATP synthesis and membrane transport. These protein complexes can also form higher order assemblies known as respiratory supercomplexes (SCs). The electron transport chain of the opportunistic pathogen Pseudomonas aeruginosa is closely linked with its ability to invade host tissue, tolerate harsh conditions, and resist antibiotics but is poorly characterized. Here, we determine the structure of a P. aeruginosa SC that forms between the quinol:cytochrome c oxidoreductase (cytochrome bc₁) and one of the organism's terminal oxidases, cytochrome cbb

SUBMITTER: Di Trani JM 

PROVIDER: S-EPMC10556555 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature