A wireless, battery-free device enables oxygen generation and immune protection of therapeutic xenotransplants in vivo.

ABSTRACT: The immune isolation of cells within devices has the potential to enable long-term protein replacement and functional cures for a range of diseases, without requiring immune suppressive therapy. However, a lack of vasculature and the formation of fibrotic capsules around cell immune-isolating devices limits oxygen availability, leading to hypoxia and cell death in vivo. This is particularly problematic for pancreatic islet cells that have high O₂ requirements. Here, we combine bioelectronics with encapsulated cell therapies to develop the first wireless, battery-free oxygen-generating immune-isolating device (O₂-Macrodevice) for the oxygenation and immune isolation of cells in vivo. The system relies on electrochemical water splitting based on a water-vapor reactant f

SUBMITTER: Krishnan SR 

PROVIDER: S-EPMC10556620 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature