Lack of associations of microRNAs with severe NAFLD in people living with HIV: discovery case-control study.

ABSTRACT:

Background & objective

Nonalcoholic fatty liver disease (NAFLD) is highly prevalent in people living with HIV (PLWH) and the expression of some microRNAs could be useful as biomarkers for the diagnosis of NAFLD. The aim of this study was to identify patterns of differential expression of microRNAs in PLWH and assess their diagnostic value for NALFD.

Methods

A discovery case-control study with PLWH was carried out. The expression of miRNAs was determined using HTG EdgeSeq technology. Cases were defined as patients with severe NAFLD and controls as patients without NAFLD, characterized using the controlled attenuation parameter (CAP). Cases and controls were matched 1:1 for age, sex, BMI, CD4+ lymphocyte count, active HCV infection, and ART regimen.

Results

Serum 2,083

SUBMITTER: Frias M 

PROVIDER: S-EPMC10556652 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature