Dynamic alterations in the amplitude of low-frequency fluctuation in patients with cerebral small vessel disease.

ABSTRACT:

Background and purpose

Previous studies have focused on the changes of dynamic and static functional connections in cerebral small vessel disease (CSVD). However, the dynamic characteristics of local brain activity are poorly understood. The purpose of this study was to investigate the dynamic cerebral activity changes in patients with CSVD using the dynamic amplitude of low-frequency fluctuation (d-ALFF).

Methods

A total of 104 CSVD patients with cognitive impairment (CSVD-CI, n = 52) or normal cognition (CSVD-NC, n = 52) and 63 matched healthy controls (HCs) were included in this study. Every participant underwent magnetic resonance imaging scans and a battery of neuropsychological examinations. The dynamics of spontaneous brain activity were assessed using d

SUBMITTER: Song J 

PROVIDER: S-EPMC10556663 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature