Stilbenoid compounds inhibit NF-κB-mediated inflammatory responses in the Drosophila intestine.

ABSTRACT:

Introduction

Stilbenoid compounds have been described to have anti-inflammatory properties in animal models in vivo, and have been shown to inhibit Ca2+-influx through the transient receptor potential ankyrin 1 (TrpA1).

Methods

To study how stilbenoid compounds affect inflammatory signaling in vivo, we have utilized the fruit fly, Drosophila melanogaster, as a model system. To induce intestinal inflammation in the fly, we have fed flies with the intestinal irritant dextran sodium sulphate (DSS).

Results

We found that DSS induces severe changes in the bacteriome of the Drosophila intestine, and that this dysbiosis causes activation of the NF-κB transcription factor Relish. We have taken advantage of the DSS-model to study the anti-inflammato

SUBMITTER: Aalto AL 

PROVIDER: S-EPMC10556681 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature