An alternative vaccine target for bovine Anaplasmosis based on enolase, a moonlighting protein.

ABSTRACT: The discovery of new targets for preventing bovine anaplasmosis has moved away from focusing on proteins that have already been extensively studied in Anaplasma marginale, including the Major Surface Proteins, Outer Membrane Proteins, and Type IV Secretion System proteins. An alternative is moonlighting or multifunctional proteins, capable of performing various biological functions within various cellular compartments. There are several reports on the role of moonlighting proteins as virulence factors in various microorganisms. Moreover, it is known that about 25% of all moonlighting is involved in the virulence of pathogens. In this work, for the first time, we present the identification of three enolase proteins (AmEno01, AmEno15, and AmEno31) in the genome of Mexican strains of <

SUBMITTER: Quiroz-Castaneda RE 

PROVIDER: S-EPMC10556744 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature