Mathematical models disentangle the role of IL-10 feedbacks in human monocytes upon proinflammatory activation.

ABSTRACT: Inflammation is one of the vital mechanisms through which the immune system responds to harmful stimuli. During inflammation, proinflammatory and anti-inflammatory cytokines interplay to orchestrate fine-tuned and dynamic immune responses. The cytokine interplay governs switches in the inflammatory response and dictates the propagation and development of the inflammatory response. Molecular pathways underlying the interplay are complex, and time-resolved monitoring of mediators and cytokines is necessary as a basis to study them in detail. Our understanding can be advanced by mathematical models that enable to analyze the system of interactions and their dynamical interplay in detail. We, therefore, used a mathematical modeling approach to study the interplay between prominent proinflammat

SUBMITTER: Nikaein N 

PROVIDER: S-EPMC10556785 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature