Intraoperative ticagrelor removal via hemoadsorption during on-pump coronary artery bypass grafting.

ABSTRACT:

Objectives

Patients on ticagrelor undergoing urgent cardiac surgery are at high risk for perioperative bleeding complications. We sought to determine whether intraoperative hemoadsorption could remove ticagrelor and lower circulating drug concentrations.

Methods

The hemoadsorption device was incorporated in the cardiopulmonary bypass (CPB) circuit and remained active for the duration of the pump run. Blood samples were collected before and after CPB. The main objective of the current analysis was to compare mean total plasma ticagrelor levels (ng/mL) at baseline with ticagrelor levels obtained at the end of CPB. Plasma ticagrelor levels were measured at a certified outside laboratory (LabConnect). Data are presented as mean ± standard deviation.

Results

A total of 11

SUBMITTER: Hassan K 

PROVIDER: S-EPMC10556833 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature