Potential effect of antidepressants on remission from cocaine use disorder - A nationwide matched retrospective cohort study.

ABSTRACT:

Background

Cocaine use disorder (CUD) is a significant public health issue for which there is no Food and Drug Administration-approved pharmacotherapy. Depressive disorders are common psychiatric comorbidity amongst individuals with CUD.

Methods

A retrospective cohort study was conducted among 161,544 patients diagnosed with CUD and depression to evaluate the effectiveness of 13 antidepressants on CUD remission. For any antidepressant found to be associated with CUD remission that had an additional indication, we conducted an additional analysis to evaluate the effectiveness of the candidate drug in patients with CUD with that indication. We then analyzed publicly genomic and functional databases to identify potential explanatory mechanisms of action of the candidate drug in

SUBMITTER: Gao Z 

PROVIDER: S-EPMC10556849 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature