Is High-Dose Tranexamic Safe in Spine Surgery? A Systematic Review and Meta-Analysis.

ABSTRACT:

Study design

Literature review and meta-analysis.

Objectives

Single-center series may be underpowered to detect whether high-dose (HD) tranexamic acid (TXA) confers a higher risk of complications. We sought to determine the safety and efficacy of HD TXA as compared to low-dose (LD) or placebo.

Methods

A systematic literature review was performed to find studies where spine surgery patients were given HD TXA (loading dose ≥30 mg/kg). Complication rates were pooled, and meta-analyses performed on outcomes of interest. Articles were evaluated for risk of bias and a strength of evidence assessment was given for each conclusion.

Results

Twenty three studies (n = 2331) were included. The pooled medical complication rate was 3.2% in pediatric patients, 8.2% in adults.

SUBMITTER: Akosman I 

PROVIDER: S-EPMC10556905 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature