Mitochondrial heteroplasmic shifts reveal a positive selection of breast cancer.

ABSTRACT:

Background

Breast cancer is, despite screening, not always detected early enough and is together with other tumor types known to shed genetic information in circulation. Unlike single-copy nuclear DNA, mitochondrial DNA (mtDNA) copies range from 100s to 10,000s per cell, thus providing a potentially alternative to identify potential missing cancer information in circulation at an early stage.

Methods

To characterize mitochondrial mutation landscapes in breast cancer, whole mtDNA sequencing and bioinformatics analyses were performed on 86 breast cancer biopsies and 50 available matched baseline cancer-free whole blood samples from the same individuals, selected from a cohort of middle-aged women in Sweden. To determine whether the mutations can be detected in blood plasma pri

SUBMITTER: Li Y 

PROVIDER: S-EPMC10557196 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature