Comparison of diagnostic efficiency of detecting IgG and IgE with immunoassay method in diagnosing ABPA: a meta-analysis.

ABSTRACT:

Background

Hitherto, the bulk of diagnostic criteria regards Aspergillus-specific immunoglobulin E as a key item, and regard IgG as an auxiliary method in diagnose. Nevertheless, there is no conclusive study in summarize the performance of IgG and IgE diagnosing ABPA.

Methods

We conducted a systematic review to identify studies report results of IgE and IgG detection in diagnosing ABPA. QUADAS-2 tool was used to evaluate included studies, and we applied the HSROC model to calculate the pooled sensitivity and specificity. Deeks' funnel was derived to evaluated the public bias of included studies, and Cochrane Q test and I² statistic were used to test the heterogeneity.

Results

Eleven studies were included in this study (1127 subjects and 215 for IgE and IgG)

SUBMITTER: Liu A 

PROVIDER: S-EPMC10557217 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature