Genetic and cultural adaptations underlie the establishment of dairy pastoralism in the Tibetan Plateau.

ABSTRACT:

Background

Domestication and introduction of dairy animals facilitated the permanent human occupation of the Tibetan Plateau. Yet the history of dairy pastoralism in the Tibetan Plateau remains poorly understood. Little is known how Tibetans adapted to milk and dairy products.

Results

We integrated archeological evidence and genetic analysis to show the picture that the dairy ruminants, together with dogs, were introduced from West Eurasia into the Tibetan Plateau since ~ 3600 years ago. The genetic admixture between the exotic and indigenous dogs enriched the candidate lactase persistence (LP) allele 10974A > G of West Eurasian origin in Tibetan dogs. In vitro experiments demonstrate that - 13838G > A functions as a LP allele in Tibetans. Unlike multiple LP alleles presenti

SUBMITTER: Peng MS 

PROVIDER: S-EPMC10557253 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature