Levels of type XVII collagen (BP180) ectodomain are elevated in circulation from patients with multiple cancer types and is prognostic for patients with metastatic colorectal cancer.

ABSTRACT:

Background

Collagens are the major components of the extracellular matrix (ECM) and are known to contribute to tumor progression and metastasis. There are 28 different types of collagens each with unique functions in maintaining tissue structure and function. Type XVII collagen (BP180) is a type II transmembrane protein that provides stable adhesion between epithelial cells and the underlying basement membrane. Aberrant expression and ectodomain shedding of type XVII collagen have been associated with epithelial damage, tumor invasiveness, and metastasis in multiple tumor types and may consequently be used as a potential (non-invasive) biomarker in cancer and treatment target.

Method

An ELISA targeting the type XVII collagen ectodomain (PRO-C17) was developed for use in seru

SUBMITTER: Crespo-Bravo M 

PROVIDER: S-EPMC10557271 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature