Restrictive versus high-dose oxygenation strategy in post-arrest management following adult non-traumatic cardiac arrest: a meta-analysis.

ABSTRACT:

Purpose

Neurological damage is the main cause of death or withdrawal of care in comatose survivors of cardiac arrest (CA). Hypoxemia and hyperoxemia following CA were described as potentially harmful, but reports were inconsistent. Current guidelines lack specific oxygen targets after return of spontaneous circulation (ROSC).

Objectives

The current meta-analysis assessed the effects of restrictive compared to high-dose oxygenation strategy in survivors of CA.

Methods

A structured literature search was performed. Randomized controlled trials (RCTs) comparing two competing oxygenation strategies in post-ROSC management after CA were eligible. The primary end point was short-term survival (≤ 90 days). The meta-analysis was prospectively registered in PROSPERO database (C

SUBMITTER: Macherey-Meyer S 

PROVIDER: S-EPMC10557287 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature