DVT: a high-throughput analysis pipeline for locomotion and social behavior in adult Drosophila melanogaster.

ABSTRACT:

Background

Drosophila melanogaster is excellent animal model for understanding the molecular basis of human neurological and motor disorders. The experimental conditions and chamber design varied between studies. Moreover, most previously established paradigms focus on fly trace detection algorithm development. A comprehensive understanding on how fly behaves in the chamber is still lacking.

Results

In this report, we established 74 unique behavior metrics quantifying spatiotemporal characteristics of adult fly locomotion and social behaviors, of which 49 were newly proposed. By the aiding of the developed analysis pipeline, Drosophila video tracking (DVT), we identified siginificantly different patterns of fly behavior confronted with different chamber height, fly density,

SUBMITTER: Mi K 

PROVIDER: S-EPMC10557313 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature