The expression of matrix metalloproteinase 2, 9 and 11 in Ethiopian breast cancer patients.

ABSTRACT:

Introduction

Matrix metalloproteinases (MMPs) play a pathophysiological role in cancer initiation and progression. Numerous studies have examined an association between MMP-2, MMP-9, and MMP-11 expression and clinicopathological characteristics of breast cancer (BC); however, no research has been done on the MMP expression levels in BC cases from Ethiopia.

Materials and methods

A total of 58 formalin-fixed paraffin-embedded breast tissue samples encompassing 16 benign breast tumors and 42 BC were collected. The RNA was extracted and quantitative reverse-transcription PCR was performed. GraphPad Prism version 8.0.0 was used for statistical analysis.

Results

The MMP-11 expression levels were significantly higher in breast cancer cases than in benign breast tumors (P = 0

SUBMITTER: Belachew EB 

PROVIDER: S-EPMC10557335 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature