Investigating the causal interplay between sleep traits and risk of acute myocardial infarction: a Mendelian randomization study.

ABSTRACT:

Background

Few studies have investigated the joint effects of sleep traits on the risk of acute myocardial infarction (AMI). No previous study has used factorial Mendelian randomization (MR) which may reduce confounding, reverse causation, and measurement error. Thus, it is prudent to study joint effects using robust methods to propose sleep-targeted interventions which lower the risk of AMI.

Methods

The causal interplay between combinations of two sleep traits (including insomnia symptoms, sleep duration, or chronotype) on the risk of AMI was investigated using factorial MR. Genetic risk scores for each sleep trait were dichotomized at their median in UK Biobank (UKBB) and the second survey of the Trøndelag Health Study (HUNT2). A combination of two sleep traits constitutin

SUBMITTER: Arora N 

PROVIDER: S-EPMC10557341 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature