Molecular characterization of human peripheral nerves using desorption electrospray ionization mass spectrometry imaging.

ABSTRACT: Desorption electrospray ionization mass spectrometry imaging (DESI-MSI) is a molecular imaging method that can be used to elucidate the small-molecule composition of tissues and map their spatial information using two-dimensional ion images. This technique has been used to investigate the molecular profiles of variety of tissues, including within the central nervous system, specifically the brain and spinal cord. To our knowledge, this technique has yet to be applied to tissues of the peripheral nervous system (PNS). Data generated from such analyses are expected to advance the characterization of these structures. The study aimed to: (i) establish whether DESI-MSI can discriminate the molecular characteristics of peripheral nerves and distinguish them from surrounding tissues and (ii) ass

SUBMITTER: Tomalty D 

PROVIDER: S-EPMC10557387 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature