Diabetes mellitus drug discovery: insights into targeting feline and human amylin with small molecules.

ABSTRACT:

Background

Type 2 diabetes (T2D) is a health concern for both humans and cats, with cases rising over the past decade. Around 70% of patients from either species exhibit pancreatic aggregates of islet amyloid polypeptide (IAPP), a protein that proves toxic upon misfolding. These misfolded protein aggregates congregate in the islets of Langerhans of the pancreas, diminishing the capability of β-cells to produce insulin and further perpetuating disease.

Objective

Our team's drug discovery program is investigating newly synthesized compounds that could diminish aggregates of both human and feline IAPP, potentially disrupting the progression of T2D.

Material and methods

We prepared 24 compounds derived from diaryl urea, as ureas have previously demonstrated great potentia

SUBMITTER: Moore KBE 

PROVIDER: S-EPMC10557562 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature