Independent prognostic biomarker FERMT3 associated with immune infiltration and immunotherapy response in glioma.

ABSTRACT:

Background

Adult glioma progresses rapidly and has a poor clinical outcome. The focal adhesion protein Kindlin-3 (encoded by the FERMT3 gene) participates in tumor development, drug resistance, and progression. However, the relationship between Kindlin-3 and glioma prognosis or immune microenvironment is poorly understood.

Methods

We comprehensively analyzed the expression, prognostic value, mutation landscape, functional enrichment, immune infiltration, and therapeutic role of FERMT3 in glioma using multiple datasets and validated Kindlin-3 expression in clinical tissue specimens by immunohistochemistry and multiple immunofluorescence staining.

Results

FERMT3 is an independent predictor of glioma prognosis and is highly expressed in glioblastoma

SUBMITTER: Zhuo S 

PROVIDER: S-EPMC10557566 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature