Ancient genomic linkage couples metabolism with erythroid development.

ABSTRACT: Generation of mature cells from progenitors requires tight coupling of differentiation and metabolism. During erythropoiesis, erythroblasts are required to massively upregulate globin synthesis then clear extraneous material and enucleate to produce erythrocytes^1-3. Nprl3 has remained in synteny with the α-globin genes for >500 million years⁴, and harbours the majority of the α-globin enhancers⁵. Nprl3 is a highly conserved inhibitor of mTORC1, which controls cellular metabolism. However, whether Nprl3 itself serves an erythroid role is unknown. Here, we show that Nprl3 is a key regulator of erythroid metabolism. Using Nprl3-deficient fetal liver and adult competitive bone marrow - fetal liver chimeras, we show that NprI3 is required for sufficient e

SUBMITTER: Preston AE 

PROVIDER: S-EPMC10557585 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature