Bed Nucleus of the Stria Terminalis (BNST) neurons containing the serotonin 5HT_2c receptor modulate operant alcohol self-administration behavior in mice.

ABSTRACT: The serotonin 5HT_2c receptor has been widely implicated in the pathophysiology of alcohol use disorder (AUD), particularly alcohol seeking and the affective consequences of chronic alcohol consumption. However, little is known about the brain sites in which 5HT_2c exerts its effects on specific alcohol-related behaviors, especially in females. Here, we investigated the effects of site-specific manipulation of the 5HT_2c receptor system in the BNST on operant alcohol self-administration behaviors in adult mice of both sexes, including the acquisition and maintenance of fixed-ratio responding, motivation for alcohol (progressive ratio), and quinine-adulterated responding for alcohol on a fixed-ratio schedule (punished alcohol seeking). Knockdown of 5HT_2c</

SUBMITTER: Flanigan ME 

PROVIDER: S-EPMC10557639 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature