Seizure Event Detection Using Intravital Two-Photon Calcium Imaging Data.

ABSTRACT:

Significance

Genetic cellular calcium imaging has emerged as a powerful tool to investigate how different types of neurons interact at the microcircuit level to produce seizure activity, with newfound potential to understand epilepsy. Although many methods exist to measure seizure-related activity in traditional electrophysiology, few yet exist for calcium imaging.

Aim

To demonstrate an automated algorithmic framework to detect seizure-related events using calcium imaging - including the detection of pre-ictal spike events, propagation of the seizure wavefront, and terminal spreading waves for both population-level activity and that of individual cells.

Approach

We developed an algorithm for precise recruitment detection of population and individual cells during seizu

SUBMITTER: Stern MA 

PROVIDER: S-EPMC10557641 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature