<i>Syngap1</i> Promotes Cognitive Function through Regulation of Cortical Sensorimotor Dynamics.

ABSTRACT: Perception, a cognitive construct, emerges through sensorimotor integration (SMI). The genetic mechanisms that shape SMI required for perception are unknown. Here, we demonstrate in mice that expression of the autism/intellectual disability gene, Syngap1, in cortical excitatory neurons is required for formation of somatomotor networks that promote SMI-mediated perception. Cortical Syngap1 expression was necessary and sufficient for setting tactile sensitivity, sustaining tactile object exploration, and promoting tactile learning. Mice with deficient Syngap1 expression exhibited impaired neural dynamics induced by exploratory touches within a cortical-thalamic network known to promote attention and perception. Disrupted neuronal dynamics were associated with circuit-spe

SUBMITTER: Vaissiere T 

PROVIDER: S-EPMC10557642 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature