Analysis of nasopharyngeal microbiome patterns in Zambian infants with fatal acute febrile illness.

ABSTRACT:

Introduction

Associative connections have previously been identified between nasopharyngeal infections and infant mortality. The nasopharyngeal microbiome may potentially influence the severity of these infections.

Methods

We conducted an analysis of a longitudinal prospective cohort study of 1,981 infants who underwent nasopharyngeal sampling from 1 week through 14 weeks of age at 2-3-week intervals. In all, 27 microbiome samples from 9 of the infants in the cohort who developed fatal acute febrile illness (fAFI) were analyzed in pooled comparisons with 69 samples from 10 healthy comparator infants. We completed 16S rRNA amplicon gene sequencing all infant NP samples and characterized the maturation of the infant NP microbiome among the fAFI(+) and fAFI(-) infant cohorts.

SUBMITTER: Odom AR 

PROVIDER: S-EPMC10557644 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature