Septins Enable T Cell Contact Guidance <i>via</i> Amoeboid-Mesenchymal Switch.

ABSTRACT: Lymphocytes exit circulation and enter in-tissue guided migration toward sites of tissue pathologies, damage, infection, or inflammation. By continuously sensing and adapting to the guiding chemo-mechano-structural properties of the tissues, lymphocytes dynamically alternate and combine their amoeboid (non-adhesive) and mesenchymal (adhesive) migration modes. However, which mechanisms guide and balance different migration modes are largely unclear. Here we report that suppression of septins GTPase activity induces an abrupt amoeboid-to-mesenchymal transition of T cell migration mode, characterized by a distinct, highly deformable integrin-dependent immune cell contact guidance. Surprisingly, the T cell actomyosin cortex contractility becomes diminished, dispensable and antagonistic to mese

SUBMITTER: Zhovmer AS 

PROVIDER: S-EPMC10557721 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature