TgLaforin, a glucan phosphatase, reveals the dynamic role of storage polysaccharides in <i>Toxoplasma gondii</i> tachyzoites and bradyzoites.

ABSTRACT: The asexual stages of Toxoplasma gondii are defined by the rapidly growing tachyzoite during the acute infection and by the slow growing bradyzoite housed within tissue cysts during the chronic infection. These stages represent unique physiological states, each with distinct glucans reflecting differing metabolic needs. A defining feature of T. gondii bradyzoites is the presence of insoluble storage glucans known as amylopectin granules (AGs), the function of which remains largely unexplored during the chronic infection. The presence of storage glucans has more recently been established in tachyzoites, a finding corroborated by specific labeling with the anti-glycogen antibody IV58B6. The T. gondii genome encodes activities needed for glucan turnover inlcuding: a gluca

SUBMITTER: Murphy RD 

PROVIDER: S-EPMC10557770 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature