The potential health and economic impacts of new tuberculosis vaccines under varying delivery strategies in Delhi and Gujarat, India: a modelling study.

ABSTRACT:

Background

India has the largest tuberculosis burden globally, but this burden varies nationwide. All-age tuberculosis prevalence in 2021 ranged from 747/100,000 in Delhi to 137/100,000 in Gujarat. Previous modelling has demonstrated the benefits and costs of introducing novel tuberculosis vaccines in India overall. However, no studies have compared the potential impact of tuberculosis vaccines in regions within India with differing tuberculosis disease and infection prevalence. We used mathematical modelling to investigate how the health and economic impact of two potential tuberculosis vaccines, M72/AS01_E and BCG-revaccination, could differ in Delhi and Gujarat under varying delivery strategies.

Methods

We applied a compartmental tuberculosis model separately fo

SUBMITTER: Clark RA 

PROVIDER: S-EPMC10557803 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature