Noninvasive Quantification of Radiation-Induced Lung Injury using a Targeted Molecular Imaging Probe.

ABSTRACT:

Rationale

Radiation-induced lung injury (RILI) is a progressive inflammatory process commonly seen following irradiation for lung cancer. The disease can be insidious, often characterized by acute pneumonitis followed by chronic fibrosis with significant associated morbidity. No therapies are approved for RILI, and accurate disease quantification is a major barrier to improved management.

Objective

To noninvasively quantify RILI, utilizing a molecular imaging probe that specifically targets type 1 collagen in mouse models and patients with confirmed RILI.

Methods

Using a murine model of lung radiation, mice were imaged with EP-3533, a type 1 collagen probe to characterize the development of RILI and to assess disease mitigation following losartan treatment. The human

SUBMITTER: Abston E 

PROVIDER: S-EPMC10557816 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature