Hematologic setpoints are a stable and patient-specific deep phenotype.

ABSTRACT: The complete blood count is an important screening tool for healthy adults and is the most commonly ordered test at periodic physical exams. However, results are usually interpreted relative to one-size-fits-all reference intervals, undermining the goal of precision medicine to tailor medical care to the needs of individual patients based on their unique characteristics. Here we show that standard complete blood count indices in healthy adults have robust homeostatic setpoints that are patient-specific and stable, with the typical healthy adult's set of 9 blood count setpoints distinguishable from 98% of others, and with these differences persisting for decades. These setpoints reflect a deep physiologic phenotype, enabling improved detection of both acquired and genetic determinants of he

SUBMITTER: Foy BH 

PROVIDER: S-EPMC10557837 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature