Immune checkpoint-related gene polymorphisms are associated with acute myeloid leukemia.

ABSTRACT:

Background

Chemotherapy is still the standard regimen for treating acute myeloid leukemia (AML) and its disappointing efficacy requires the urgent need for new therapeutic targets. It is well known that immune response plays an increasingly significant role in the pathogenesis of AML.

Methods

We detected nine single nucleotide polymorphisms (SNPs) in immune checkpoint-related genes, including PD1, LAG3, TIM3, and TIGIT in 285 AML inpatients and 324 healthy controls. SNP genotyping was performed on the MassARRAY platform. Furthermore, we analyzed the relationship between the susceptibility and prognosis of AML and the selected SNPs.

Results

Our results showed that rs2227982 and rs10204525 in PD1 were significantly associated with susceptibility to AML after false disco

SUBMITTER: Wu Y 

PROVIDER: S-EPMC10557852 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature