ELOA promotes tumor growth and metastasis by activating RBP1 in gastric cancer.

ABSTRACT:

Background

Elongin A (ELOA), our previous work revealed, serves as a novel tumor suppressor in colorectal cancer. However, the function and mechanism of ELOA in other cancer types, including gastric cancer (GC), remain to be elucidated.

Methods

The expression of ELOA was measured by quantitative reverse transcription-polymerase chain reaction and western blot. The effects of ELOA on GC growth and metastasis were assessed through a series of in-vitro and in-vivo assays. Furthermore, the potential mechanism of ELOA was revealed by RNA sequencing, dual luciferase reporter assay, chromatin immunoprecipitation, and rescue experiments in GC.

Results

We uncovered increased expression of ELOA in GC tissues compared with paired normal tissues via bioinformatic analyses and our

SUBMITTER: Tian L 

PROVIDER: S-EPMC10557880 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature