Gastroesophageal reflux disease and risk of cancer: Findings from the Korean National Health Screening Cohort.

ABSTRACT:

Aim

Little is known about the association of cancers other than esophageal adenocarcinoma with gastroesophageal reflux disease (GERD). This study aimed to examine the association between GERD and the risk of different types of cancer.

Methods

A cohort study was conducted using data from the National Health Screening Cohort. We included 10,261 GERD patients and 30,783 non-GERD individuals who were matched in a 1:3 ratio by age and sex. All participants were followed-up until cancer diagnosis, death, or end of the study (December 31, 2015). Hazard ratios were calculated using the Cox proportional hazards model, adjusting for smoking and alcohol consumption, physical activity, body mass index, income, area, and Charlson Comorbidity Index.

Results

The median follow-up tim

SUBMITTER: Tran CL 

PROVIDER: S-EPMC10557881 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature