Perioperative opioids and survival outcomes in resectable head and neck cancer: A systematic review.

ABSTRACT:

Background

Opioids are a mainstay in pain control for oncologic surgery. The objective of this systematic review is to evaluate the associations of perioperative opioid use with overall survival (OS) and disease-free survival (DFS) in patients with resectable head and neck cancer (HNC).

Methods

A systematic review of PubMed, SCOPUS, and CINAHL between 2000 and 2022 was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies investigating perioperative opioid use for patients with HNC undergoing surgical resection and its association with OS and DFS were included.

Results

Three thousand three hundred seventy-eight studies met initial inclusion criteria, and three studies representing 562 patients (intraoperative op

SUBMITTER: Mastrolonardo EV 

PROVIDER: S-EPMC10557889 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature