The tryptophan-kynurenine pathway in immunomodulation and cancer metastasis.

ABSTRACT:

Introduction

The activation of the kynurenine pathway in cancer progression and metastasis through immunomodulatory pathways has drawn attention to the potential for kynurenine pathway inhibition. The activation of the kynurenine pathway, which results in the production of kynurenine metabolites through the degradation of tryptophan, promotes the development of intrinsically malignant properties in cancer cells while facilitating tumour immune escape. In addition, kynurenine metabolites act as biologically active substances to promote cancer development and metastasis.

Methods

A literature review was conducted to investigate the role of the tryptophan-kynurenine pathway in immunomodulation and cancer metastasis.

Results

Evidence suggests that several enzymes and metab

SUBMITTER: Basson C 

PROVIDER: S-EPMC10557908 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature