Identification and validation of hub genes involved in foam cell formation and atherosclerosis development via bioinformatics.

ABSTRACT:

Background

Foam cells play crucial roles in all phases of atherosclerosis. However, until now, the specific mechanisms by which these foam cells contribute to atherosclerosis remain unclear. We aimed to identify novel foam cell biomarkers and interventional targets for atherosclerosis, characterizing their potential mechanisms in the progression of atherosclerosis.

Methods

Microarray data of atherosclerosis and foam cells were downloaded from the Gene Expression Omnibus (GEO) database. Differentially expression genes (DEGs) were screened using the "LIMMA" package in R software. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and Gene Ontology (GO) annotation were both carried out. Hub genes were found in Cytoscape after a protein-protein intera

SUBMITTER: Teng D 

PROVIDER: S-EPMC10557941 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature