High LYRM4-AS1 predicts poor prognosis in patients with glioma and correlates with immune infiltration.

ABSTRACT:

Background

Many researches proved that non-coding RNAs are important in glioma development. We screened the differentially expressed genes through The Cancer Genome Atlas (TCGA) database and identified the molecule LYRM4-AS1 associated with prognosis. As a lncRNA, the expression level and role of LYRM4-AS1 in glioma are inconclusive. Therefore, we attempted to assess the clinical significance, expression and related mechanisms of LYRM4-AS1 in glioma by employing cell experiments and an integrative in silico methodology.

Methods

RNA-seq data were obtained from UCSC XENA and TCGA datasets. The Gene Expression Omnibus (GEO) database was used to download glioma-related expression profile data. The LYRM4-AS1 expression level was evaluated. Survival curves were constructed

SUBMITTER: Wang HY 

PROVIDER: S-EPMC10557942 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature