In-stent restenosis after percutaneous coronary intervention: emerging knowledge on biological pathways.

ABSTRACT: Percutaneous coronary intervention (PCI) has evolved significantly over the past four decades. Since its inception, in-stent restenosis (ISR)-the progressive reduction in vessel lumen diameter after PCI-has emerged as the main complication of the procedure. Although the incidence of ISR has reduced from 30% at 6 months with bare-metal stents to 7% at 4 years with drug-eluting stents (DESs), its occurrence is relevant in absolute terms because of the dimensions of the population treated with PCI. The aim of this review is to summarize the emerging understanding of the biological pathways that underlie ISR. In-stent restenosis is associated with several factors, including patient-related, genetic, anatomic, stent, lesion, and procedural characteristics. Regardless of associated factors, ther

SUBMITTER: Pelliccia F 

PROVIDER: S-EPMC10558044 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature