Timing of initiation of anti-retroviral therapy predicts post-treatment control of SIV replication.

ABSTRACT: One approach to 'functional cure' of HIV infection is to induce durable control of HIV replication after the interruption of antiretroviral therapy (ART). However, the major factors that determine the viral 'setpoint' level after treatment interruption are not well understood. Here we combine data on ART interruption following SIV infection for 124 total animals from 10 independent studies across 3 institutional cohorts to understand the dynamics and predictors of post-treatment viral control. We find that the timing of treatment initiation is an important determinant of both the peak and early setpoint viral levels after treatment interruption. During the first 3 weeks of infection, every day of delay in treatment initiation is associated with a 0.22 log10 copies/ml decrease in post-rebou

SUBMITTER: Pinkevych M 

PROVIDER: S-EPMC10558076 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature