MRI and amino acid PET detection of whole-brain tumor burden.

ABSTRACT:

Background

[¹⁸F]fluciclovine amino acid PET has shown promise for detecting brain tumor regions undetected on conventional anatomic MRI scans. However, it remains unclear which of these modalities provides a better assessment of the whole brain tumor burden. This study quantifies the performance of [¹⁸F]fluciclovine PET and MRI for detecting the whole brain tumor burden.

Methods

Thirteen rats were orthotopically implanted with fluorescently transduced human glioblastoma cells. Rats underwent MRI (T1- and T2-weighted) and [¹⁸F]fluciclovine PET. Next brains were excised, optically cleared, and scanned ex vivo with fluorescence imaging. All images were co-registered using a novel landmark-based registration to enable a spatial comparison. The tu

SUBMITTER: Chen P 

PROVIDER: S-EPMC10558180 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature