Changes in gut microbiota and cytokines following laparoscopic sleeve gastrectomy are associated with cognitive function improvement.

ABSTRACT:

Purpose

Variations of cytokines and gut microbiota diversity with improved cognitive function in patients with obesity following bariatric surgery were poorly understood. The aim of this study was to testify the relationship among gut microbiota, cytokines and cognitive function in patients with obesity before and after laparoscopic sleeve gastrectomy (LSG).

Methods

Forty patients were enrolled in this study. Demographics, and serum and stool specimens were collected from all patients before and 3 months after LSG. The Montreal Cognitive Assessment (MoCA) scale, as well as assessment of immediate and delayed memory were used to evaluate self-perceived cognitive improvement after LSG.

Results

LSG resulted in significant weight loss and improvement in cognitive function

SUBMITTER: Chen W 

PROVIDER: S-EPMC10558312 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature